Quantifying heterogeneous AAV capsid loading using mass photometry
Adeno-associated viruses (AAVs) are used in approved gene therapies to deliver genetic cargo to target cells. Distinguishing
heterogeneously filled AAV capsids is an important aspect of sample characterization when developing these therapeutics.
Here, data collected by Pharmaron Gene Therapy show that mass photometry can distinguish populations of AAV capsids
with heterogeneous loading of genomic content and quantify the proportion of each population in a sample. Mass
photometry measurements take only minutes, require minimal training and have very low titer requirements.
More Application Notes
Browse through our catalogue of application notes highlighting some recent case studies featuring mass photometry.
Mass photometry of nucleic acids
Mass photometry of nanocages
Mass photometry on SARS-CoV-2