top of page

Quantifying heterogeneous AAV capsid loading using mass photometry
Application Note

Adeno-associated viruses (AAVs) are used in approved gene therapies to deliver genetic cargo to target cells. Distinguishing heterogeneously filled AAV capsids is an important aspect of sample characterization when developing these therapeutics.

Here, data collected by Pharmaron Gene Therapy show that mass photometry can distinguish populations of AAV capsids with heterogeneous loading of genomic content and quantify the proportion of each population in a sample. Mass photometry measurements take only minutes, require minimal training and have very low titer requirements.

Quantifying heterogeneous AAV capsid loading using mass photometry.png

More Application Notes

Browse through our catalogue of application notes highlighting some recent case studies featuring mass photometry.

Mass photometry of nucleic acids

Mass photometry of nanocages

Mass photometry on SARS-CoV-2

Mass photometry on AAVs

bottom of page