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Featured Publications

Check out all the newest publications, reviews, and articles featuring mass photometry. Use the filters to find specific application areas, biomolecule types, and more.

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October 2023

The structural mechanism of dimeric DONSON in replicative helicase activation

Molecular Cell (2023)

Cvetkovic, M.A., Passaretti, P., Butryn, A., Reynolds-Winczura, A., Kingsley, G., Skagia, A., Fernandez-Cuesta, C., Poovathumkadavil, D., George, R., Chauhan, A.S., Jhujh, S.S., Stewart, G.S., Gambus, A., Costa, A.

Keywords:

DNA replication initiation, replicative helicase, DONSON, cryo-EM, Xenopus egg extract, primordial dwarfism

September 2023

Development of a 1:1-binding biparatopic anti-TNFR2 antagonist by reducing signaling activity through epitope selection

Communications Biology (2023)

Akiba, H., Fujita, J., Ise, T., Nishiyama, K., Miyata, T., Kato, T., Namba, K., Ohno, H., Kamada, H., Nagata, S., & Tsumoto, K.

Keywords:

Antibody therapy, Biophysical chemistry, Cryoelectron microscopy, Protein design

October 2023

The structural mechanism of dimeric DONSON in replicative helicase activation

Molecular Cell (2023)

Cvetkovic, M.A., Passaretti, P., Butryn, A., Reynolds-Winczura, A., Kingsley, G., Skagia, A., Fernandez-Cuesta, C., Poovathumkadavil, D., George, R., Chauhan, A.S., Jhujh, S.S., Stewart, G.S., Gambus, A., Costa, A.

Keywords:

DNA replication initiation, replicative helicase, DONSON, cryo-EM, Xenopus egg extract, primordial dwarfism

October 2023

Antagonistic roles of canonical and Alternative-RPA in disease-associated tandem CAG repeat instability

Cell (2023)

Gall-Duncan, T., Luo, J., Jurkovic, C., Fischer, L.A., Fujita, K., Deshmukh, A.L., Harding, R.J., Tran, S., Mehkary, M., Li, V., Leib, D.E., Chen, R., Tanaka, H., Mason, A.G., Lévesque, D., Khan, M., Razzaghi, M., Prasolava, T., Lanni, S., Sato, N., Pearson, C.E.

Keywords:

Replication protein A (RPA), Alternative replication protein A (Alt-RPA), RPA1, RPA2, RPA3, RPA4, tandem repeat expansions, trinucleotide CAG repeat expansions, Huntington's disease (HD), Spinocerebellar ataxia type 1 (SCA1), DNA repair (FAN1, MSH2, MSH3, MSH6, HTT), slipped-DNA, BioID protein interactome

October 2023

Structural insights into the complex of oncogenic KRas4BG12V and Rgl2, a RalA/B activator

Life Science Alliance (2023)

Tariq, M., Ikeya, T., Togashi, N., Fairall, L., Kamei, S., Mayooramurugan, S., Abbott, L.R., Hasan, A., Bueno-Alejo, C., Sukegawa, S., Romartinez-Alonso, B., Muro Campillo, M.A., Hudson, A.J., Ito, Y., Schwabe, J.W.R., Dominguez, C., Tanaka, K.

Keywords:

Structural biology, cancer, therapeutics, crystal structure, complex formation

October 2023

A morpheein equilibrium regulates catalysis in phosphoserine phosphatase SerB2 from Mycobacterium tuberculosis

Communications Biology (2023)

Pierson, E., De Pol, F., Fillet, M., & Wouters, J.

Keywords:

Biophysical chemistry, microbiology, Mycobacterium, therapeutics, tuberculosis, enzyme

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