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October 2023
The structural mechanism of dimeric DONSON in replicative helicase activation
Molecular Cell (2023)
Cvetkovic, M.A., Passaretti, P., Butryn, A., Reynolds-Winczura, A., Kingsley, G., Skagia, A., Fernandez-Cuesta, C., Poovathumkadavil, D., George, R., Chauhan, A.S., Jhujh, S.S., Stewart, G.S., Gambus, A., Costa, A.
Keywords:
DNA replication initiation, replicative helicase, DONSON, cryo-EM, Xenopus egg extract, primordial dwarfism
September 2023
Development of a 1:1-binding biparatopic anti-TNFR2 antagonist by reducing signaling activity through epitope selection
Communications Biology (2023)
Akiba, H., Fujita, J., Ise, T., Nishiyama, K., Miyata, T., Kato, T., Namba, K., Ohno, H., Kamada, H., Nagata, S., & Tsumoto, K.
Keywords:
Antibody therapy, Biophysical chemistry, Cryoelectron microscopy, Protein design
October 2023
The structural mechanism of dimeric DONSON in replicative helicase activation
Molecular Cell (2023)
Cvetkovic, M.A., Passaretti, P., Butryn, A., Reynolds-Winczura, A., Kingsley, G., Skagia, A., Fernandez-Cuesta, C., Poovathumkadavil, D., George, R., Chauhan, A.S., Jhujh, S.S., Stewart, G.S., Gambus, A., Costa, A.
Keywords:
DNA replication initiation, replicative helicase, DONSON, cryo-EM, Xenopus egg extract, primordial dwarfism
October 2023
Antagonistic roles of canonical and Alternative-RPA in disease-associated tandem CAG repeat instability
Cell (2023)
Gall-Duncan, T., Luo, J., Jurkovic, C., Fischer, L.A., Fujita, K., Deshmukh, A.L., Harding, R.J., Tran, S., Mehkary, M., Li, V., Leib, D.E., Chen, R., Tanaka, H., Mason, A.G., Lévesque, D., Khan, M., Razzaghi, M., Prasolava, T., Lanni, S., Sato, N., Pearson, C.E.
Keywords:
Replication protein A (RPA), Alternative replication protein A (Alt-RPA), RPA1, RPA2, RPA3, RPA4, tandem repeat expansions, trinucleotide CAG repeat expansions, Huntington's disease (HD), Spinocerebellar ataxia type 1 (SCA1), DNA repair (FAN1, MSH2, MSH3, MSH6, HTT), slipped-DNA, BioID protein interactome
October 2023
Structural insights into the complex of oncogenic KRas4BG12V and Rgl2, a RalA/B activator
Life Science Alliance (2023)
Tariq, M., Ikeya, T., Togashi, N., Fairall, L., Kamei, S., Mayooramurugan, S., Abbott, L.R., Hasan, A., Bueno-Alejo, C., Sukegawa, S., Romartinez-Alonso, B., Muro Campillo, M.A., Hudson, A.J., Ito, Y., Schwabe, J.W.R., Dominguez, C., Tanaka, K.
Keywords:
Structural biology, cancer, therapeutics, crystal structure, complex formation