Mass photometry of nucleic acids

Application Note

Mass photometry allows quantification of the mass distribution of biomolecules in solution. Its use in analysing the purity of proteins, characterising their oligomeric states, and quantifying their protein-protein interactions is established.


However, the application of mass photometry to characterise other biomolecules is less well explored, including nucleic acids. Here, we show how to use mass photometry to measure the mass, size and abundance of DNA, in the range of 100 to 5000 base pairs.

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