Mass Photometry Webinars

We have hosted a range of webinars, where we discuss applications of mass photometry as well as how to get the best out of our technology. You can watch any of them on this page. To stay updated on upcoming webinars, please check out our events calendar.

Investigating membrane protein complexes with mass photometry

The speakers will present work studying two examples of macromolecular complexes formed by eukaryotic membrane proteins. In both cases, mass photometry was crucial to addressing highly relevant physiological questions. They will explain what mass photometry can do, and what makes it suitable for studies of membrane protein complexes.

Automated Mass Photometry : Easing the Path to Biomolecular Characterisation

In this webinar, we discuss in detail, automated mass photometry and show data on some of its most attractive applications—such as screening and titration assays. We illustrate how automation and the associated improvement in reproducibility can make biomolecular characterization with mass photometry even easier (TwoMP Auto Launch Webinar)

Probing Antibody Binding to the SARS-CoV-2 Spike Protein

Characterizing the mass of proteins and their complexes has a wide range of applications. However, the large degree of heterogeneity present in some biological systems has historically posed a near-unsurmountable challenge to traditional native mass spectrometry and classic structural biology techniques. To overcome this, researchers are turning to new, single-particle mass analysis methods. In this webinar, Victor Yin, a postdoctoral researcher of biomolecular mass spectrometry and proteomics at Utrecht University, discusses how mass photometry and charge detection mass spectrometry enable the study of several challenging protein systems, including the interaction of full antibodies with SARS-CoV-2.

Using Mass Photometry to Quantitate CaMKII stoichiometries

Prof. Margaret Stratton (UMass Amherst) presents her work on the role of CaMKII​ in different tissues. Mass photometry helps to quantitatively determine the stoichiometry of different variants of this crucial oligomeric enzyme.

Measuring the heterogeneity of macromolecular machines by mass photometry

In this webinar, Dr Adar Sonn-Segev presents how mass photometry provides quantitative information on sample heterogeneity using minimal volumes with molecular resolution. She also discusses how this approach applies to several different workflows including chemical crosslinking and multi-step purification, comparing it to the standard tools for measuring sample purity.

Applications of Mass Photometry

In this webinar, Refeyn co-founder Prof. Justin Benesch discusses examples of mass photometry measurements for large protein complexes and draws comparisons with mass measurements obtained from native mass spectrometry and other techniques. Dr Nikolas Hundt also describes the use of mass photometry to visualise the nucleation process of actin filaments in real time.

Probing & modulating the function of the retromer endosomal trafficking complex through the novel macrocyclic peptides

In this webinar, find an explanation on how the macrocyclic peptides can be used as a novel toolbox to study retromer-mediated endosomal trafficking and for therapeutic targeting of retromer function. Highlighted, is the method mass photometry, which enables characterization of protein complexes.

Are Your AAVs Filled? Determine Rapidly with Mass Photometry

In this webinar, our product manager Svea Cheeseman provides insight into a novel mass photometry instrument tailored to address the challenges of AAV characterization. Moreover, we will see data proving its ability to reliably quantify the empty-full particle ratio for different AAV serotypes and at different purification levels, including benchmark data comparing the mass photometry solution with cryoTEM and analytical ultra-centrifugation.

Measuring Membrane Proteins with Mass-Sensitive Particle Tracking

In this webinar, Dr Nikolas Hundt (Ludwigs-Maximilian-University Munich), describes a new mass photometry strategy for unlabelled molecules diffusing on supported lipid bilayers. With this approach, called mass-sensitive particle tracking (MSPT), researchers can determine the mass distributions and diffusion characteristics of membrane-associated protein complexes and observe protein assembly dynamics on a lipid interface in real time.

Quantifying protein-protein interactions by molecular counting with mass photometry

Dr Grzegorz Piszczek (Director of the Biophysics Core Facility, NIH) and Fabian Soltermann (PhD candidate, Oxford University) discuss how mass photometry can be used to characterise and determine the purity, stoichiometry, binding affinity and kinetics of multi-protein interactions. They also cover a recent application of mass photometry: quantifying interactions of antibodies with Fc-receptors.

Measuring Molecules with Light

This webinar features our co-founder, Prof. Philipp Kukura, describing how mass photometry offers a universal way to study biomolecules, as well as its strengths and limitations.

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