Macro mass photometry for rapid viral vector characterization

An article authored by Laura Pala, one of our Product Marketing Managers, has recently been published by Eurolab magazine and also online at ScientistLive. It provides a useful overview of macro mass photometry and how it can help to speed up viral vector characterization, a key analytical step within the production pipeline for cell and gene therapies (CGT) and vaccines. 

Here’s an extract from the article detailing the need for improved viral vector analysis techniques to help inform process and optimization for vaccine and CGT development: 

Limitations of characterization techniques

Conventional characterization techniques bring limitations: Cell-based vector analysis takes days to perform, while more rapid approaches, like nanoparticle tracking analysis (NTA), provide limited characterization data. Along with a paucity of in-process analysis tools, these obstacles create a significant bottleneck at the vector characterization stage for vaccine and CGT programs. 

In light of the demand for new innovations to improve the accuracy and speed of vector analysis, macro mass photometry has emerged as a promising solution. Using light scattering to analyze particles, this novel method unlocks a host of valuable vector characterization capabilities, including rapid and accurate determination of full/empty capsid ratios, sample purity and more. 

The article moves on to cover: 

• An explanation of our new macro mass photometry technique 

• Determining adenovirus (AdV) sample purity 

• Rapid identification and quantification of functional lentiviral vector (LVV) populations 

‘Vector Victories’ is published on pages 26-29 of Eurolab, June 2024

Read the full article online at ScientistLive