An article authored by Laura Pala, one of our Product Marketing Managers, has recently been published by Eurolab magazine and also online at ScientistLive. It provides a useful overview of macro mass photometry and how it can help to speed up viral vector characterization, a key analytical step within the production pipeline for cell and gene therapies (CGT) and vaccines.Â
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Here’s an extract from the article detailing the need for improved viral vector analysis techniques to help inform process and optimization for vaccine and CGT development:Â
Limitations of characterization techniques
Conventional characterization techniques bring limitations: Cell-based vector analysis takes days to perform, while more rapid approaches, like nanoparticle tracking analysis (NTA), provide limited characterization data. Along with a paucity of in-process analysis tools, these obstacles create a significant bottleneck at the vector characterization stage for vaccine and CGT programs.Â
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In light of the demand for new innovations to improve the accuracy and speed of vector analysis, macro mass photometry has emerged as a promising solution. Using light scattering to analyze particles, this novel method unlocks a host of valuable vector characterization capabilities, including rapid and accurate determination of full/empty capsid ratios, sample purity and more.Â
The article moves on to cover:Â
An explanation of our new macro mass photometry techniqueÂ
Determining adenovirus (AdV) sample purityÂ
Rapid identification and quantification of functional lentiviral vector (LVV) populationsÂ
‘Vector Victories’ is published on pages 26-29 of Eurolab, June 2024
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