Software release 

Last updated : 12 October 2020

2.3.0

  • Added the ability to compare multiple sets of DiscoverMP results. This is done with the multiple histogram dialog which can be found under “Tools” / “Multiple histograms...”.

  • Increased analysis speed by ca. 10% by improved pipeline settings.

  • Renamed “Integral Region” to “Interval Region” for clarity. The counts displayed from an interval region is the total number of events that fall within that interval. Conversely, the counts displayed from a Gaussian fit is the integrated value of the fitted Gaussian model, not the physical number of observed events underneath the Gaussian fit.

  • Part of the histogram labels have changed how they are calculated. For Gaussian fits and interval regions, the percentage that was displayed is now the number of counts for that overlay divided by the total number of binding or unbinding events (depending on whether the overlay was made for binding or unbinding events). It used to be the number of counts for that overlay divided by the total number of counts currently visible in the histogram. The definition is displayed in a tooltip that appears when hovering the mouse over a label. For further details, please refer to the DiscoverMP user manual.

​Additional features :

  • Added the capability of automatically adding an interval region around a peak. This can be done by double-clicking near the centre of peak when the overlay tool is in interval mode.

  • Brightness metric added to score plots.

  • Motion correction is now switched on by default. You can switch it off by editing the settings.

  • Large under-the-hood overhaul of the histogram panel. The changes enable seamless switching of contrast/mass mode and histogram/KDE mode preserving overlays, axes limits, and bin widths.

  • An opt-in feature has been added to automatically send error logs to Refeyn if there is an internet connection. This will help us be able to know what errors are occurring and so be able to fix them more easily.

  • Upon batch processing completing, a sound will be played to alert you. The application's icon in the task bar will also flash orange if the window was not in focus when the processing completed. The sound can be turned off in the preferences dialog.

  • When in vertical line mode, you can now drag over a region of interest. The median value for the events in this region will then be displayed with a vertical line and a label of the contrast/mass value.

  • In the interest of simplicity, the spinbox for the median filter size in the settings dialog has been removed. This parameter is set to a good default value that should not be changed. If the user wants to change this parameter nonetheless it can be done by editing the settings file.

  • Measurement quality warnings are no longer appearing as pop-ups but instead a red exclamation mark appears at the top right corner of the application window. If the user clicks the exclamation mark a pop-up appears outlining details of the warning.

  • The feature for measurement types such as "calibrant"/"sample" and all associated features have been retired in the interest of a simpler workflow.

  • Add functionality to read compressed MP files generated with AcquireMP 2.3 and later versions.

  • The suppress motion that added temporal masks automatically has been removed. Motion correction supersedes this functionality. The suppress density functionality has also been removed.

2.3.0

  • New "Find Focus" feature that replaces the "Return to Focus" feature. Once the device has been set up and buffer has been added to the cover slide pressing the "Find Focus" button moves the sample into focus. If focus has already been found before, this will be used to speed up the procedure.

  • The sharpness metric has been improved. There should not be a significant change to the observed values.

  • Warning pop ups for high motion has been removed, instead the score limit indicators warn the user about motion.

  • The auto focus exposure warnings have been removed. They have been replaced with a button to trigger automatic exposure correction. The button will be highlighted in orange to indicate when to press it.

  • To simplify the workflow the option has been removed to save a movie as a mass calibrant, instead any measurement can be used as a mass calibration.

​Additional features: 

  • A Medium Image Size has been added and the dialog UI has been changed to make the selection more clear.

  • A new slider has been added which displays the current brightness (mean pixel exposure) of the acquisition image.

  • The view settings dialog has been moved out of the file tab and onto the main banner.

  • Recorded Acquisition movies are now automatically compressed to save on memory.

  • Users can now opt in to send usage data to Refeyn.

  • An option has been added to deactivate the license in the help dialog.

  • Advanced settings has become a global option which can be turned on or off in the preferences dialog (off by default) and individual dialog advanced buttons have been removed.

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