Applications of mass photometry
Sample purity and composition
Using mass photometry, the mass of molecules can be determined by how they interact with light. The technique benefits from low sample requirements, quick acquisition times (<2 minutes per run), and the measurement is made at a single molecule level without the need for any labels.
Protein complexes - assembly and stoichiometry
Mass photometry can quantitatively detect even very rare stoichiometries, in solution. This provides an unparalleled view of the composition of a protein solution, and an avenue to test and optimise solution conditions that may influence oligomerization or aggregation.
Mass measurement of complex biomolecules
Mass photometry allows for the measurement of not only molecules of simple composition, but also those comprising multiple biomolecular classes (e.g. glycoproteins, membrane proteins solubilised by detergent, protein-DNA complexes).
The function of proteins, and their malfunction in disease, is governed by their interactions with each themselves and with other biomolecules. Mass photometry provides a new and uniquely powerful means to quantify these interactions in terms of physically meaningful quantities.
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The unique benefits of mass photometry give it tremendous potential for both academic as well as industrial applications. Our technology has been exemplified by a variety of scientific publications, showcasing its potential for a variety of high-impact applications like drug-delivery vehicles, protein-protein interactions, antibody-research even protein aggregation underlying neurodegenerative diseases as well as its universal use with a variety of molecules.