Applications of mass photometry

Mass photometry is a recent addition to the bioanalytical toolkit. By directly measuring molecular mass in solution, it reports on fundamental properties of the sample while a native environment is maintained. It is thus applicable to a wide range of different molecules and to both basic research and drug discovery. 

Mass photometry measures mass at the single molecule level, providing insights into the composition and function of even complex samples and molecular mechanisms. This unique technology can detect and characterise proteins, nucleic acids, lipids and sugars. It provides information on structure (oligomeric state, modification), homogeneity, and function (quantifying interactions) – all in a matter of minutes and using tiny amounts of sample.

Due to its unique benefits, mass photometry addresses  a major unmet need for more efficient analytical tools. It will ultimately help accelerate science, and the discovery and development of new therapeutics.

"We have been using the Refeyn OneMP mass photometer in our biophysics lab in Gothenburg for several months now. It has been invaluable in a number of studies, ranging from simple cases of clarifying the oligomeric states of drug targets to elucidating complex binding mechanisms of small molecules. I believe Refeyn's mass photometry is a great piece of technology for any biophysics lab.”

 

- Anders Gunnarsson, Associate Principal Scientist, Discovery Sciences, AstraZeneca R&D

Sample characterisation

Protein oligomerisation

Biomolecular interactions

Macromolecular assemblies

Application Notes

Browse through our catalogue of application notes highlighting some recent case studies featuring mass photometry.

Mass photometry on SARS-CoV-2

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Mass photometry of nucleic acids

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Recent publications

Mass photometry and its range of applications have been featured in a variety of scientific and academic publications. View the latest list of publications by visiting the page below.