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Applications of mass photometry

Mass photometry is a completely new addition to the bioanalytical tool kit. By directly measuring molecular mass in solution, it reports on fundamental properties of the sample while maintaining the native environment. It is thus widely applicable to a range of different molecules and steps in both basic research and in drug discovery processes. 

Mass photometry measures mass at the single molecule level, providing insights into the composition and function of even complex samples and molecular mechanisms. This unique technology can be used to detect and characterise proteins, nucleic acids, lipids and / or sugars, providing information on structure (oligomeric state, modification), homogeneity, and function (quantifying interactions) – all in a matter of minutes, and using tiny amounts of sample.

Due to its unique benefits, mass photometry addresses  a major unmet need for more efficient analytical tools, and will ultimately help accelerate science and the discovery and development of new therapeutics.

Sample characterisation

Protein oligomerisation

Biomolecular interactions

Macromolecular assemblies

Featured Publications

Mass photometry and its range of applications have been featured in a variety of reputable publications. Browse through the most recent ones below.

Measuring the affinity of protein-protein interactions on a single-molecule level by mass photometry

Mass Photometry of

Membrane Proteins

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Single-molecule fluorescence-based approach reveals novel mechanistic insights into small heat shock protein chaperone function

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