Automated mass photometry

Automated mass photometry combines the ease and efficiency of automation with the unmatched sensitivity and simplicity of Refeyn’s molecular mass measurement technology. The automated mass photometer frees up operator time and offers enhanced precision, enabling rapid measurement of multiple samples with low sample consumption. Automation is compatible with both the OneMP and the TwoMP.

Automated mass characterisation

  • Rapid measurement of multiple samples

  • One hour of autonomous measurement

  • Ideal for screening and titration assays 

Highly reproducible data

  • Precision pipetting

  • Consistent measurements

Intuitive operation

  • A user-friendly software interface

  • Automation unit compatible with TwoMP and OneMP

Plus, all the benefits of mass photometry:

Mass measurement in solution, without the need for labels

Single molecule counting

Minimal sample required


Highly reproducible results

The liquid-handling robot autonomously analyses 14 samples in 1 hour in a highly reproducible manner.


A straightforward, repeated measurement of a sample containing the antibody IgG illustrates the precision of the automated mass photometer, which is reflected in the high degree of reproducibility of the resulting data (Fig. 1).


Figure 1A shows histograms of 12 repeated measurements of an IgG sample made using automated mass photometry. Across the wells that contain the sample, the measured mass (Fig. 1B) and total counts (Fig. 1C) show low variability.

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Figure 1 Automated mass photometry measurements are highly reproducible. Autonomously run mass photometry measurements show (A) the mass distributions of IgG forming monomers and dimers (inset: mass histograms for each well). The measured mass (B) and total counts (C) across the wells show low variability. 

To learn more about automated mass photometry and to see the data on example experiments, download our brochure

Further resources

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Webinar: Automated Mass Photometry: Easing the Path to Biomolecular Characterization

In this webinar, we discuss in detail, automated mass photometry and show data on some of its most attractive applications—such as screening and titration assays. We illustrate how automation and the associated improvement in reproducibility can make biomolecular characterization with mass photometry even easier. Register now.

Live demo : Watch automated mass photometry in action

Register for an upcoming remote demo on the TwoMP Auto, where a mass photometry expert will explain the principle behind the technology, and demo the automated mass photometer. There will also be an opportunity to ask questions in the Q&A session.