A mass photometer for automated AAV analysis
The SamuxMP Auto is the automated mass photometer for AAV characterization, autonomously measuring up to 24 samples in approximately 90 minutes. The instrument rapidly measures AAV empty/full ratios, sample purity and particle aggregation for any AAV serotype – with high precision and reproducibility.
Characterization of AAV samples
Empty/full AAV capsid ratio
Partially filled and overfilled capsids
Detection of aggregates and impurities
Rough titer estimation
24 measurements in about 90 min
Automation unit retrofittable to the SamuxMP
Minimal sample preparation
Minimal training required
GMP compliance coming soon!
Transformative AAV analytics – automated
The SamuxMP Auto offers all the advantages of AAV capsid analysis with mass photometry while adding convenience and reproducibility via automated, highly consistent sample manipulation (Fig. 1). It accurately measures empty/full capsid ratios of AAVs, and detects partially filled and overfilled AAVs in heterogeneous samples.
The SamuxMP Auto can autonomously analyze 24 samples in as little as 90 minutes, yet fits on a benchtop. Its integrated software suite allows the user to define measurement protocols, analyzes the 24 measurements on the fly, and makes it easy to plot and export the resulting data in a variety of formats.
The robotics unit can be retrofitted to existing SamuxMP instruments.
Fig. 1. The SamuxMP Auto offers autonomous and reproducible measurements. The mass histogram above shows the overlay of 22 measurements of different aliquots from the same AAV sample, illustrating the reproducibility of the measurements.
To learn more about the SamuxMP Auto and automated mass photometry of AAVs, download the brochure
Streamlining AAV characterization with automated mass photometry
In this webinar, Svea Cheeseman, Director of Product Management for Cell & Gene Therapy at Refeyn, discusses how mass photometry can be used to characterize AAV capsids – by measuring the empty/full capsid ratio for AAVs of any serotype with low sample consumption. She also introduces the SamuxMP Auto, Refeyn’s automated mass photometer for rapid and autonomous analysis of AAV samples.
Demonstrating Analytical Comparability in Analytical Development
In this webinar, Svea Cheeseman gives an overview of how mass photometry works and present the SamuxMP product line, which is tailored for the analysis of AAVs. Svea provides benchmarking data to compare mass photometry with other technologies that are gold standards for AAV characterization, and presents case studies showing the performance of the SamuxMP and SamuxMP Auto mass photometers.