top of page

A mass photometer for automated AAV analysis


Refeyn SamuxMP.png

The SamuxMP Auto is the automated mass photometer for AAV characterization, autonomously measuring up to 24 samples in approximately 90 minutes. The instrument rapidly measures AAV empty/full ratios, sample purity and particle aggregation for any AAV serotype – with high precision and reproducibility.

  • Rapid characterization of empty/full AAV capsid ratio

  • Automated technology - 24 measurements in about 90 min

  • Highly reproducible data with minimal sample preparation

  • Automation unit retrofittable to the SamuxMP

Characterization of AAV samples

  • Empty/full AAV capsid ratio 

  • Partially filled and overfilled capsids

  • Detection of aggregates and impurities

  • Rough titer estimation

Automated measurement

Easy setup

  • 24 measurements in about 90 min

  • High reproducibility

  • Automation unit retrofittable to the SamuxMP

  • Benchtop instrument

  • Minimal sample preparation

  • Minimal training required

GMP compliance coming soon!

Transformative AAV analytics – automated

The SamuxMP Auto offers all the advantages of AAV capsid analysis with mass photometry while adding convenience and reproducibility via automated, highly consistent sample manipulation (Fig. 1). It accurately measures empty/full capsid ratios of AAVs, and detects partially filled and overfilled AAVs in heterogeneous samples.

The SamuxMP Auto can autonomously analyze 24 samples in as little as 90 minutes, yet fits on a benchtop. Its integrated software suite allows the user to define measurement protocols, analyzes the 24 measurements on the fly, and makes it easy to plot and export the resulting data in a variety of formats.

The robotics unit can be retrofitted to existing SamuxMP instruments.

A sample mass histogram showing SamuxMP Auto data analyzing empty/full AAV capsid ratios.

Fig. 1. The SamuxMP Auto offers autonomous and reproducible measurements. The mass histogram above shows the overlay of 22 measurements of different aliquots from the same AAV sample, illustrating the reproducibility of the measurements.

To learn more about the SamuxMP Auto and automated mass photometry of AAVs, download the brochure

Further resources

YouTube Thumbnail (600 × 150 px) (1280 × 720 px) (2).png

Streamlining AAV characterization with automated mass photometry

In this webinar, Svea Cheeseman, Director of Product Management for Cell & Gene Therapy at Refeyn, discusses how mass photometry can be used to characterize AAV capsids – by measuring the empty/full capsid ratio for AAVs of any serotype with low sample consumption. She also introduces the SamuxMP Auto, Refeyn’s automated mass photometer for rapid and autonomous analysis of AAV samples.

Demonstrating Analytical Comparability in Analytical Development

In this webinar, James Walkinson gives an overview of how mass photometry works and present the SamuxMP product line, which is tailored for the analysis of AAVs. James provides benchmarking data to compare mass photometry with other technologies that are gold standards for AAV characterization, and presents case studies showing the performance of the SamuxMP and SamuxMP Auto mass photometers.  

Nikolas webinar
bottom of page