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Quantifying protein binding affinities using mass photometry
Protein interactions play pivotal roles in a wide range of biological processes. However, they are often highly complex, involving the binding of multivalent ligands to multiple binding sites. As a result, it can be challenging to identify the various complexes formed and assess the strength of their interactions.
Mass photometry is a fast, label-free technology that measures the molecular mass of individual biomolecules in solution, and is ideal for studying protein-protein interactions. By providing the mass distribution of biomolecules in a sample, it gives a detailed overview of the binding partners present, the complexes they form, the relative abundance of each species and the strength of their interactions.
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